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1- Metabolic Liver Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
2- Acquired Immunodeficiency Research Center, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
3- Department of Pediatrics, School of Medicine, Imam Hossein Children’s Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
4- Department of Pediatrics, School of Medicine, Imam Hossein Children’s Hospital, Isfahan University of Medical Sciences, Isfahan, Iran. , goli2291@yahoo.com
Abstract:   (159 Views)
Background and objectives: Considering the chronic immunosuppression in inflammatory bowel disease (IBD) patients, it is necessary to evaluate the course of COVID-19 in these patients. Studies have shown various results in adult IBD patients. The aim of this study was to find out the course of this infection in pediatric IBD patients. 
Methods: This was a systematic review study according to the PRISMA 2020 guideline. Scopus, PubMed, and the Web of Science were searched with a combination of “COVID-19” AND “IBD” or synonyms until October 16, 2021. Studies that have the outcomes of COVID-19 infection in patients less than 19 years of age were selected. Name of author, country, study duration and type, IBD type and drugs, and COVID-19 outcomes were extracted.
Results: From the initially retrieved 2215 articles, finally 16 articles were eligible. Totally, data from 1040 pediatric IBD patients were reported. Twenty-four patients were hospitalized, 5 patients developed Multisystem inflammatory Syndrome in children, and others had a mild disease course and were outpatient. Steroid use, severe IBD activity, and comorbidities were shown to increase disease severity and risk of hospitalization.
Conclusions: COVID-19 is a benign and self-limited disease in pediatric IBD patients. Comorbidities, steroid use, and severe IBD activity affect the patients’ outcomes.
 
Full-Text [PDF 999 kb]   (69 Downloads)    
Type of Study: Systematic Review | Subject: Pediatric Gastroenterology
Received: 2022/06/6 | Accepted: 2022/08/10

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