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1- Prevalence and Associated Risk Factors of Neonatal Hypoglycemia in Iran: A Systematic Review and Meta-Analysis
2- Traditional and Complementary Medicine Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran. , mmfir@yahoo.com
3- Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
4- Medical Student at Medical School, Mazandaran University of Medical Sciences, Sari, Iran.
5- Department of Traditional Persian Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Abstract:   (78 Views)
Background: Neonatal hypoglycemia is the most common metabolic abnormality affecting newborns and contributes to increased morbidity and mortality. The present systematic review and meta-analysis aims to explore the prevalence and associated risk factors of neonatal hypoglycemia in Iran.
Materials and Methods: A systematic search was performed in Iranian and international databases, including SID, MagIran, Barakat Knowledge Network System, PubMed, Scopus, Web of Science, and the Google Scholar search engine, were searched for relevant articles using valid keywords. The search process was updated until 28 September 2021. Data were analyzed using STATA 14 software, and the significance level was considered P<0.05 for all tests.
Results: In fourteen reviewed articles with a sample size of 18217, the prevalence of hypoglycemia in Iranian newborns was 29% [95%CI: 21%, 37%, P=0.000] (64% in boys and 37% in girls). The hypoglycemia prevalence was 67% in infants born via C-section compared to 24% in those delivered vaginally. The lowest and highest prevalence of neonatal hypoglycemia was observed in Mashhad (12%) and Arak (53%), respectively. The most common risk factors for neonatal hypoglycemia in Iran were infant’s prematurity (61%), septicemia (45%), respiratory distress syndrome(RDS) (26%), small for gestational age (SGA) (26%), maternal diabetes (21%), hypocalcemia (19%), Intrauterine Growth Restriction (IUGR)
 (9%) and perinatal asphyxia (8%).
Conclusion: Neonatal hypoglycemia is highly prevalent in Iran, affecting nearly one-third of Iranian newborns. Hypoglycemia was nearly two times more prevalent in boys than girls and 2.5 times more common in infants born by C-section than in those delivered vaginally. Furthermore, prematurity was reportedly the most common risk factor for neonatal hypoglycemia in Iran.
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Type of Study: Meta-analysis Review | Subject: Neonatology
Received: 2022/06/21 | Accepted: 2023/01/3

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