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1- Physical Medicine and Rehabilitation Research Center, Tabriz University of Medical Science, Tabriz, Iran
2- Pediatric Health Research Center, Tabriz University of Medical Science, Tabriz, Iran
3- Physical Medicine and Rehabilitation Research Center, Tabriz University of Medical Science, Tabriz, Iran , n.t.tabrizi@gmail.com
4- Evidence Based Medicine Research Center, Tabriz University of Medical Science, Tabriz, Iran
5- Physical Medicine and Rehabilitation Department, Children’s Medical Center, Tehran University of Medical Science, Tehran, Iran
6- Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract:   (97 Views)
Context: Guillain-Barre Syndrome (GBS) is an immune-mediated polyneuropathy and a common cause of acute ascending weakness in children.
Objective: The objective of this study was to report long-term disability and poor outcome predictors of GBS in children.
Data sources: MEDLINE (via Pubmed), Embase, Cochrane Library, Web of Science and Scopus database were searched for relevant studies until April 2022, with the designated search strategy, using MeSH terms and free keywords.
Study selection: Studies evaluating functional outcomes of GBS in children with at least one-year of follow-up were included. All studies achieved acceptable quality for inclusion
Data extraction: After selecting studies based on inclusion criteria, data were extracted based on Modified standardized Joanna Briggs Institute data extraction tool and checked for methodological quality of studies using JBI critical appraisal tool.
Results: Fourteen studies were included in this systematic review consisting of 1141 patients (647 males, 466 females and 28 unclassified). Follow-up duration varied from one year to 11 years. Prevalence of GBS subtype were as follows: AIDP 46.6%, AMAN 30.2%, AMSAN 6.8% and Miller fisher 6.1%. The most-reported poor outcome after at least one year of follow-up was walking disabilities and gait disorders. Motor deficits and weakness, sensory complains including pain or paresthesia and fatigue were other prevalent residual symptoms. Axonal form of GBS was the most reported poor outcome predictor, followed by Hughes disability score >3, delayed independent walking, artificial ventilation and rapid progression of symptoms.
Conclusion: Despite the good prognosis of GBS in children, they could suffer long-term sequels, especially in walking abilities and gait. The axonal form is considered an important poor predictive factor.
Full-Text [PDF 1337 kb]   (38 Downloads)    
Type of Study: Systematic Review | Subject: Pediatric Neurology
Received: 2022/07/25 | Accepted: 2022/11/26

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