Volume 11, Issue 1 (1-2023)                   J. Pediatr. Rev 2023, 11(1): 47-58 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Salehabadi N, Moallem Savasari A, Nahvi A. Cytokines, Minerals, Total Antioxidant Capacity, Nitric Oxide, and Salivary Characteristics as Biomarkers Associated With Early Childhood Caries: A Narrative Review. J. Pediatr. Rev 2023; 11 (1) :47-58
URL: http://jpr.mazums.ac.ir/article-1-497-en.html
1- Student Research Committee, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran.
2- Department of Pediatric Dentistry, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran. , azamnahvi@yahoo.com
Abstract:   (904 Views)
Background: Early childhood caries (ECC) is one of the multifactorial, acute, and progressive types of tooth decay. Some salivary biomarkers are associated with this disease. 
Objectives: The data we used in our review were searched from articles published between 1950 to 2021 and using early childhood caries (ECC), children, saliva, salivary biomarkers, salivary characteristics, salivary minerals, cytokines, total antioxidant capacity (TAC) and nitric oxide (NO) as keywords, collected from official web pages (Scopus, PubMed, Embase and Google scholar) and documents published from different international institutions. 
Methods: The search was limited to articles published in the English language. After the abstract screening, the full text of 194 relevant studies was reviewed. Finally, 101 relevant studies were selected.
Results: Cytokines with the potential to affect ECC include interleukin (IL)-1 (IL-1β), IL-6, IL-8, IL-10, IL-12, tumor necrosis factor-alpha (TNFα), a soluble cluster of differentiation (sCD)14-cluster of differentiation 14 (CD14), CD63 and vascular endothelial growth factor (VEGF). The minerals associated with the ECC are calcium (Ca), phosphate (PO43-), fluoride (F), magnesium (Mg), iron (Fe), and lead (Pb). 
Conclusion: Some characteristics of saliva that seem to concern ECC include salivary pH, salivary total protein, salivary total lipid, salivary buffering capacity, and saliva flow rate. Other vital factors observed to have significant effects on the ECC process involve total antioxidant capacity (TAC) and nitric oxide (NO).
Full-Text [PDF 546 kb]   (545 Downloads) |   |   Full-Text (HTML)  (179 Views)  
Type of Study: Narrative Review | Subject: Dentistry
Received: 2022/10/4 | Accepted: 2022/12/29 | Published: 2023/01/1

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Pediatrics Review

Designed & Developed by : Yektaweb