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1- Student Research Committee, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran
2- Department of Pediatric Dentistry, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran , Azamnahvi@yahoo.com
Abstract:   (98 Views)
Context: Early childhood caries (ECC) is one of the multifactorial, acute and progressive types of tooth decay. Some salivary biomarkers are associated with this disease.
Evidence Acquisition: The data we used in our review were searched from articles published between 1950 to 2021 and using early childhood caries (ECC), children, saliva, salivary biomarkers, salivary characteristics, salivary minerals, cytokines, Total antioxidant capacity (TAC) and Nitric oxide (NO) as keywords, collected from official web pages (Scopus, PubMed, Embase and Google scholar) and documents published from different international institutions. The search was limited to articles published in English language. After abstract screening, full-text of 194 related studies were reviewed. Finally, 101 most related studies were selected.
Resultsand Conclusions: Cytokines with the potential to affect ECC include Interleukin-1(IL-1) (IL-1β), Interleukin-6(IL-6), Interleukin-8(IL-8), Interleukin-10(IL-10), Interleukin-12(IL-12), TNFα, sCD14) CD14), CD63 and Vascular endothelial growth factor (VEGF). The minerals associated with the ECC are Calcium(Ca), Phosphate(PO43-), Fluoride(F), Magnesium(Mg), Iron(Fe) and lead(Pb). Some Characteristics of saliva that seem to concern ECC: Salivary pH, salivary total protein, salivary total lipid, salivary buffering capacity, and saliva flow rate. Other important factors observed to have significant effects on the ECC process involve Total antioxidant capacity(TAC) and Nitric oxide (NO).
Full-Text [PDF 873 kb]   (37 Downloads)    
Type of Study: Narrative Review | Subject: Dentistry
Received: 2022/10/4 | Accepted: 2023/01/3

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