Volume 11, Issue 2 (4-2023)                   J. Pediatr. Rev 2023, 11(2): 125-134 | Back to browse issues page

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Farhadi R. Hepatobiliary Involvement in Neonates With COVID-19 Infection: A Narrative Review. J. Pediatr. Rev 2023; 11 (2) :125-134
URL: http://jpr.mazums.ac.ir/article-1-498-en.html
Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran. , rfarhadi@mazums.ac.ir
Abstract:   (583 Views)
Background: The most common symptoms in neonates with severe COVID-19 infection have been respiratory problems. The virus may adversely affect organs such as the liver. 
Methods: Studies focusing solely on liver involvement in newborns with COVID-19 infection were searched in Pubmed, Scopus, and Google Scholar databases. Eight studies were finally reviewed.
Results: Direct viral invasion (COVID-19-induced hepatitis or systemic inflammatory response) and drug-induced may contribute to liver damage in neonates. SARS-CoV-2 may be the latest spark in toxoplasmosis, other agents, rubella, cytomegalovirus, herpes infections, and fetal liver involvement may be induced by transplacental transmission. 
Conclusions: Hepatic dysfunction is infrequent but important in neonates with COVID-19 infection and the mechanism of liver damage associated with COVID-19 may differ from that in adults.
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Type of Study: Review Article | Subject: Neonatology
Received: 2022/10/6 | Accepted: 2023/01/21 | Published: 2023/04/1

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