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Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran. ,
Abstract:   (29 Views)
Context: The most common symptoms in neonates with severe COVID-19 infection have been respiratory problems. The virus may adversely affect organs such as the liver.
Evidence acquisition: Studies focusing solely on liver involvement in newborns with COVID-19 infection were searched in Pubmed, Scopus, and Google scholar databases. Eight studies were finally reviewed.
Results: Direct viral invasion (COVID-19-induced hepatitis or systemic inflammatory response) and drug-induced may contribute to liver damage in neonates. SARS-CoV-2 may be the latest spark in TORCH infection, and fetal liver involvement may be induced by transplacental transmission.
Conclusion: Hepatic dysfunction is infrequent but important in neonates with COVID-19 infection and the mechanism of liver damage associated with COVID-19 may differ from that in adults.
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Type of Study: Narrative Review | Subject: Neonatology
Received: 2022/10/6 | Accepted: 2023/01/21

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