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Faeghe Baryar Langroudi1, Hamid Mohammadjafari2, Hani Rostami Rad1, Mohaddeseh Momeni1, Maedeh Guran1, Mohammad Reza Navaeifar 
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1- Pediatric department, Bou Ali-Sina Hospital, faculty of medicine, Mazandaran University of Medical Sciences, Sari, Iran.
2- Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
3- Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran. , Dr.navaifar@gmail.com
2- Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
3- Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran. , Dr.navaifar@gmail.com
Abstract: (88 Views)
Background: Acute kidney injury is one of the common complications in the pediatric intensive care unit.
Objectives: This study designed to evaluate acute kidney injury’s frequency and etiologic causes and its course in critically ill children.
Methods: This cross-sectional study was conducted in a tertiary training pediatric intensive care unit. Acute kidney injury is defined based on the pRIFLE definition. Analysis of possible variables contributing to acute kidney injury was made using data up to 48 hours before the onset of renal failure.
Results: In 255 patients, the median age was 18(IQR, 6-60) months. The common causes of admission were infectious diseases (50.2%) and neurologic disorders (25.9%).
Acute kidney injury occurred in 63(24.7%) patients. Prerenal Acute kidney injury occurred in 43(68.3%) patients, renal 11(17.5%), and post-renal 2(3.2%), and 7(11.1%) unspecified. Patients with the Risk, Injury, Failure, and Loss stages of the pRIFLE definition were 40(63.5%), 14(22.2%), 6(9.5%), and 3(4.8%), respectively. The length of hospital stay was significantly higher in acute kidney injury patients, (P=0.041). After controlling for other risk factors, acute kidney injury was higher in patients with lower age, higher PRISM III scores, multiple organ dysfunction, Leukocytosis, hypernatremia, and acidosis (P<0.05).
Conclusions: acute kidney injury is a significant concern in pediatric intensive care unit, which is linked to prolonged hospital stay. The lower age, higher mortality scores, multiple organ dysfunction, Leukocytosis, hypernatremia, and acidosis are risk factors for the next 48 hours acute kidney injury.
Objectives: This study designed to evaluate acute kidney injury’s frequency and etiologic causes and its course in critically ill children.
Methods: This cross-sectional study was conducted in a tertiary training pediatric intensive care unit. Acute kidney injury is defined based on the pRIFLE definition. Analysis of possible variables contributing to acute kidney injury was made using data up to 48 hours before the onset of renal failure.
Results: In 255 patients, the median age was 18(IQR, 6-60) months. The common causes of admission were infectious diseases (50.2%) and neurologic disorders (25.9%).
Acute kidney injury occurred in 63(24.7%) patients. Prerenal Acute kidney injury occurred in 43(68.3%) patients, renal 11(17.5%), and post-renal 2(3.2%), and 7(11.1%) unspecified. Patients with the Risk, Injury, Failure, and Loss stages of the pRIFLE definition were 40(63.5%), 14(22.2%), 6(9.5%), and 3(4.8%), respectively. The length of hospital stay was significantly higher in acute kidney injury patients, (P=0.041). After controlling for other risk factors, acute kidney injury was higher in patients with lower age, higher PRISM III scores, multiple organ dysfunction, Leukocytosis, hypernatremia, and acidosis (P<0.05).
Conclusions: acute kidney injury is a significant concern in pediatric intensive care unit, which is linked to prolonged hospital stay. The lower age, higher mortality scores, multiple organ dysfunction, Leukocytosis, hypernatremia, and acidosis are risk factors for the next 48 hours acute kidney injury.
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