Volume 11, Issue 3 (7-2023)                   J. Pediatr. Rev 2023, 11(3): 231-244 | Back to browse issues page

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Rezai M S, Rostami-Maskopaee F, Navaeifar M R, Hajialibeig A, Gooran M, Haghighi Aski B, et al . Multisystem Inflammatory Syndrome Mortality Following COVID-19 in Iranian Children: A Case Series and Literature Review. J. Pediatr. Rev 2023; 11 (3) :231-244
URL: http://jpr.mazums.ac.ir/article-1-535-en.html
1- Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
2- Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran. , rostamiraha5@gmail.com
3- Department of Pediatrics, Ali Asghar Children’s Hospital, Iran University of Medical Sciences, Tehran, Iran.
4- Department of Pediatrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract:   (337 Views)
Background: Children generally are less contaminated by COVID-19 than other age groups, but multisystem inflammatory syndrome-children (MIS-C) can cause severe outcomes in some children. The information about MIS-C patient mortality is limited, and the cause of mortality may vary by geographical region. Therefore, we performed this case series study to report the clinical features and treatment of MIS-C patients associated with COVID-19 who died in selected referral hospitals in Iran.
Case Presentation: We presented 9 cases of deceased MIS-C patients hospitalized from March 2020 to September 2021. The median age of deceased patients was 89 months (interquartile range: 8-162 mo). Five patients (55%) were male. The COVID-19 reverse transcription polymerase chain reaction (PCR) or serology test was positive in 7 children (77%). About 80% of the patients had comorbidities, most commonly obesity. All the patients were febrile at admission, and 77.78% had a fever for over 5 days. Respiratory, cardiac, and gastrointestinal signs were the most common. On admission, 6 patients were transferred to the pediatric intensive care unit. All patients received intravenous immunoglobulin and steroids. 
Conclusions: The most common organ failure was lung, heart, liver, and kidney, but the main cause of death was cardiopulmonary failure. Early diagnosis and management of MIS-C are necessary to prevent severe complications and death.
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Type of Study: Case & Review | Subject: Pediatric infection disease
Received: 2023/04/30 | Accepted: 2023/06/12 | Published: 2023/07/1

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