Volume 12, Issue 1 (1-2024)                   J. Pediatr. Rev 2024, 12(1): 73-78 | Back to browse issues page

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Jaksic M, Martinovic M, Nedovic Vukovic M. Targeting Copper Dyshomeostasis as a Pathophysiological Basis of Childhood Obesity: Latest Facts. J. Pediatr. Rev 2024; 12 (1) :73-78
URL: http://jpr.mazums.ac.ir/article-1-585-en.html
1- Department of Laboratory Diagnostics, Institute of Children’s Diseases, Clinical Center of Montenegro, Podgorica, Montenegro. , marinaj@ucg.ac.me
2- Department of Pathological Physiology, Faculty of Medicine, University of Montenegro, Podgorica, Montenegro.
3- Department of Health Statistics, Center of Health System Evidence and Research in Public Health, Institute for Public Health of Montenegro, Podgorica, Montenegro.
Abstract:   (615 Views)
Context: Childhood pre-obesity and obesity rates have been rapidly growing worldwide over the past decades. Copper homeostasis is gaining increasing attention in the physiopathology of obesity. Strong evidence indicates that a disturbance of copper homeostasis plays an important role in the development of obesity and its related comorbidities. Under physiological conditions, copper plays a significant role in regulatory, immunologic, and antioxidant functions resulting in protection against inflammation and oxidative stress, and consequently against the known comorbidities of obesity. Nevertheless, despite the growing body of research, information about copper status in obesity, particularly in childhood obesity, is scarce. 
Evidence Acquisition: This brief narrative review examines the latest data published in the last five years using various databases, such as PubMed, Scopus, Unpaywall (COBISS), and EBSCO to emphasize the major current findings in research related to this topic. 
Results: The most recent studies have yielded strong evidence in support of altered copper status in childhood obesity; nevertheless.
Conclusions: Further studies are needed to clarify the role of copper in the physiopathology of childhood obesity.
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Type of Study: Narrative Review | Subject: Pediatric Endocrinology
Received: 2023/12/5 | Accepted: 2023/12/29 | Published: 2024/01/1

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